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Description

The risk did not vary substantially by age (5-100 years) in the clinical trials analyzed

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Results A forward genetic screen identifies unc1 as a modulator of polyQ aggregation To expand our knowledge of the signalling pathways controlling protein homeostasis, we performed a chemical mutagenesis screen for genes regulating protein aggregation in a worm model of polyQ diseases

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Skrzypek M, Wdowiak A, Panasiuk L, Stec M, Szczygie K, Zybaa M, et al

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Breaking this self-perpetuating cycle requires the activation of the endogenous defense system that counteracts oxidative and inflammatory stressors

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Vial planning: how many 5mg vials do you need Planning your vial supply prevents interruptions in your protocol

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