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Typically people do not start to experience symptoms until after they are 30 years old, and the average age of diagnosis is 60

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[118] Methionine synthase [edit] Methionine synthase, coded by MTR gene, is a methyltransferase enzyme which uses the MeB 12 and reaction type 2 to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine

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For determining chronic exposure levels, plasma was obtained 48 h following dose 24 of vehicle or L2-Cmu by i.p