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Importantly, the selection of the transporter for brain delivery of drugs can be affected not only by expression profiles at the BBB and brain parenchyma with regards to drug target localization, but also by the structural features of the substrates

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[243] [245] Presumably due to its rate-limited activation by red blood cells, intravenous administration of lisdexamfetamine shows greatly delayed time to peak and reduced peak levels compared to intravenous administration of an equivalent dose of dextroamphetamine

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