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PLGA-based nanoparticles: An overview of biomedical applications

Overall, GPX4 inhibitors could have a combined effect on eliminating senescent cells in the tumour and tumour microenvironment and the subset of highly plastic, mesenchymal-like cells that promote therapy resistance

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These extensive viral protein interactions with host-specific cellular targets could trigger severe human metabolic reprogramming/dysregulation (HMRD), a rewiring of sugar-, amino acid-, lipid-, and nucleotide-metabolism(s), as well as altered or impaired bioenergetics, immune dysfunction, and redox imbalance in the body