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Laboratory studies in some adult tumors and in neuroblastoma have shown that sometimes BSO needs to be combined with higher doses of melphalan to kill more cancer cells

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Ecotoxicol Environ Saf 290:117736

Refer to Table 2: DOAC dosing and therapeutic considerations based on indication for more details on DOAC dosing and therapeutic considerations and Appendix A: DOAC Drug Interactions for more information on drug interactions