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Histological evidence has shown that the activated T cells cross the BBB, invade the CNS, and congregate around small venules to trigger localized inflammation (Kuhlmann et al., 2017)

It also manages oxidative stress, particularly in dopaminergic neurons, by activating the Nrf2-antioxidant response elements (ARE) pathway and increasing the expression of antioxidant enzymes

Eur J Haematol 60:267268

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Compared to commercially available tablets, which release the two drugs within 2 h, this bicompartmental system provides a more controlled and sustained release