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Similarly, reducing the Sirtuin activity with inhibitors (EX-527) during the second hypo-inflammatory stages may reverse the hibernating endothelium and vasculature, improve neutrophilic function, clear the debris, aid with effective oxidative phosphorylation and mitochondrial biogenesis, and healing, and may improve survival [11, 49]

In a further aspect of this embodiment, the compound has the structure of: A further embodiment of the present invention is a pharmaceutical composition

Vitamin C: Essential for the body development and function, also plays an important role in immune function

As the treatment with gene therapy modalities, such as mRNA in enzyme replacement therapy, is chronic, accumulating LNPs in tissues over repeated administration may result in adverse health effects