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Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article

Renal and total body clearance are 0.31 +/- 0.06 and 0.83 +/- 0.07 L/h, respectively

Use during pregnancy and lactation should be limited to cases where the benefits outweigh the risks, as high-dose parenteral administration has not been fully studied in these populations

Even individuals who eat a balanced diet may struggle with proper absorption

Other anticoagulants that might make a person more vulnerable to internal bleeding include apixaban ( Eliquis ) and rivaroxaban ( Xarelto )