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Urgent research is required to identify synergistic combinations (e.g., FSP1 inhibitors with GPX4 inhibitors, ferroptosis inducers with IDO1/m6A inhibitors, and ferroptosis inducers with immune checkpoint blockade) that can simultaneously bypass multiple resistance pathways across diverse GBM subclones

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211 However, the potential value of vitamin A supplements in pregnant women with HIV remains questionable, particularly as some studies have indicated that vitamin A supplementation may increase the HIV load in breast milk 212 and may potentially elevate the risk of HIV transmission from mother to child