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Together, these findings highlight histone crotonylation as a stress-sensitive epigenetic mechanism that regulates synaptic plasticity and depressive-like behaviors, primarily via CDYLEZH2VGF signaling

NICE guidelines for weight management emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery

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More precisely, it is an antiplatelet drug