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2018/14933-2 and 2019/16444-1) and the Brazilian National Council for Scientific and Technological Development (grant No

At the same time, copper can destabilize vitamin C

In biodegradable carrier development, biocompatible polymers such as PLGA and natural polysaccharides are modified through surface engineering techniques (e.g., PEGylation) to reduce immunogenicity (Plumb et al., 2023), nanocarriers are functionalized with immunomodulatory agents (e.g., siRNA targeting inflammatory mediators) to activate therapeutic pathways such as cGAS-STING signaling (Nagarajan et al., 2023)

Area-under-curve (AUC) analysis was performed in Python measuring the AUC of the lethal fraction versus time

Foot faults were defined as any point at which the mouse stepped through the metal grid or gripped the plastic beam instead of the wire grid