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doi: 10.3390/jcm10235698 43

Another macrolide, FK506, was already known for its immunosuppressive properties, being successful as a transplant drug (tacrolimus), but its mechanism of action differed from that of rapamycin

Emerging cellular functions of the lipid metabolizing enzyme 15-lipoxygenase-1

In summary, by modulating immune-cell function, rebalancing lymphocyte subsets, and reprogramming core signaling networks, probiotics operate through an integrated cellular-to-molecular network to correct immune dysregulation in UC, offering a multi-target strategy to restore intestinal immune homeostasis