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doi: 10.1038/ni.1969 22 KochMATucker-HeardGPerdueNRKillebrewJRUrdahlKBCampbellDJ

Penile erection mainly depends on the activation of NO/cGMP signal pathway and the function of PDE5 is to block the decomposition of cyclic guanosine monophosphate (cGMP) ( PDE5Is are the first-line treatment for erectile dysfunction ( In addition to acting on PDE5 of cavernous smooth muscle, PDE5I also inhibits PDE5 and its isozymes in blood vessels, viscera, skeletal muscle, platelets, and other tissues, causing reactions in multiple systems

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The key factor affecting the switch from antioxidant to prooxidant properties of carotenoids has been attributed to the partial pressure of oxygen, typically high in the lungs