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The most common causes of hyperammonemia in children are severe liver failure and inherited metabolic diseases

Rojo (Ed.), Aerobic utilization of hydrocarbons, oils, and lipids

Monophasic inhibition of SERCA2a activity has been reported in SR vesicles from canine, rabbit, and rat cardiac tissues at a variable concentration range ( 2+ concentration induced by LCAC superfusion ( 2+ release from the SR, regardless of RyR2-dependency, LCACs appear to alter both SR Ca 2+ uptake and release in a manner that promotes cytosolic Ca 2+ overload and can be translated to other reports of arrhythmogenic and inotropic effects of LCACs

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however, it should be emphasised that this model is hypothetical and requires further evaluation before being translated to practice (Figures 1 and 2)