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Methods: Male Wistar rats were subjected to a chow (CHOW) diet or a free-choice (fc) diet of either chow, saturated fat and liquid sugar (fcHFHS), chow and saturated fat (fcHF), or chow and liquid sugar (fcHS) for 4 weeks

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248 In addition, IgG can promote the senescence phenotype of macrophages and microglia, release inflammatory factors such as IL-6 and TNF-, form a systemic chronic inflammatory environment, and accelerate multiorgan aging

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This review summarizes the mechanisms by which MPs exposure induces gut microbiota dysbiosis and skin damage from an integrated gutskin axis perspective, highlighting their interplays relevance

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These processes are tightly regulated by the HPG axis, culminating in the production of spermatozoa from spermatogonial stem cells (SSC) (57)

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For lipid reporter experiments, HEK293 cells were co-transfected with plasmids with AKT-PH::GFP and shRNA against KIAA1109 (Sigma-Aldrich, TRCN0000263343 with 73% knockdown efficiency), incubated for 48 h and imaged by confocal microscopy for membrane localized GFP

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