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[6] Anti-Fibrotic Signaling Thymulin gene expression in asthma models reduced airway remodeling markers: [3] Decreased TGF- and VEGF expression Reduced collagen fiber deposition in airways Attenuated smooth muscle hypertrophy in terminal bronchioles Prevented subepithelial fibrosis and mucous cell hyperplasia Earlier work showed thymulin reduced bleomycin-induced cytokine production and inhibited pulmonary fibrosis

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In recent years, the content of diacyl-containing PUFAs (PC-PUFA2s) has been found to increase significantly in vivo after fatty acid or phospholipid treatment