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Patients should use supplements that meet BOMSS specifications and always follow the guidance of their bariatric dietitian or surgical team, as individual requirements vary based on blood test results and clinical assessment

Inhibition of tyrosinase (the key enzyme of melanogenesis): Direct inhibition: Thiol group binding with the copper-containing active site of the enzyme Indirect inactivation: Exerted via the antioxidant effect of glutathione that leads to quenching of free radicals and peroxides Switching production of eumelanin to phaeomelanin Modulation of the depigmenting properties of other antimelanogenic principles Table No * N * F * 100] / W Where VU = Titrant volume of sample (ml) Vb = Titrant volume of blank (ml) N = Titrant Normality F = Equivalence Factor W = Weight of Sample (mg) Acceptance Criteria: 98.0% - 101% on the dried basis

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We then performed GWAS for HGA/GR and MET/TYR at each time point while adjusting for age, sex, and PCs 15

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