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111 AMPK senses intracellular AMP levels and, when activated, regulates cell metabolism, including autophagy, cell growth, protein synthesis, glycolysis, and fatty acid oxidation

However, MDA-MB-231 cells exposed to 1% O 2 for 5 days and then reoxygenated to 5% O 2 (the highest oxygen concentration in tumors formed by MDA-MB-231 cells 2 ) retain increased levels of both HIF-1 pNF-kB and MUC1-C as compared to cells cultured under 20% O 2 (Supplementary Fig

Fecal matter from metformin-treated mice attenuates intestinal ferroptosis induced by IIRI To investigate the role of the gut microbiota in the anti-ferroptosis effect of metformin, we established a dirty cage group by allowing mice to feed on metformin-modulated feces from the MET group

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