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8:1) using the DIMSCAN cytotoxicity assay

10.1016/0162-0134(92)84051-N 81 El-DemerdashE.AliA

In epilepsy, P2Y 1 receptor overactivation perturbs intracellular calcium dynamics and increases glutamate release, thereby intensifying seizure activity

Future strategies will likely emphasize combinatorial regimens, optimized in terms of target hierarchy, temporal dynamics, and dosage to maximize benefit while minimizing adverse effects

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