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In amyloid precursor protein plus presenilin-1 (APP/PS1) mice, Nrf2 overexpression caused by antioxidant therapy has been demonstrated to improve neuronal apoptosis, increase thioredoxin-1 (TRX-1), and prevent the formation of NLRP3 inflammatory bodies [109]

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Increased lipid peroxidation as a hallmark of ferroptosis in CF cells Mechanistically, an increase in lipid hydroperoxides is the key downstream feature of ferroptosis [14]

A sample with milli Q water added instead of H2O2 will be included as a negative control