In the liver model, proliferating HepaRG cells were used as an adequate alternative to human primary hepatocytes, the "gold standard" for in vitro drug testing, due to their availability, comparable CYP enzyme expression and presence of relevant efflux and uptake transporters 65,66,67
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This works well for an empty stomach scenario where absorption is fast
The effectiveness depends on the strain and dosage, so quality matters
The patients who SPF religiously, including on cloudy days, get the visible results
