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Here, we discuss whether the loss of nutrients associated with disc degeneration limits the effectiveness of biologic approaches, and indicate that this neglected problem requires investigation if clinical application of such therapies is to succeed

The concept of bioavailability may, in part, also explain why the same dose may cause toxicity by one route (IV) but not the other (smoking)

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Indeed, the mitochondria influence vascular function through various mechanisms, such as heightened ROS production in the bloodstream and aldehyde dehydrogenase (ALDH) deficiency