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Mutations in the GBA1 gene which encodes the lysosomal enzyme glucocerebrosidase (GCase) constitute a major genetic risk factor for PD [201, 202], and recent experiments have demonstrated that GCase activity contributes to the clearance of -synuclein aggregates [203, 204]

doi: 10.1073/pnas.96.18.10039 52 WatkinsPAHowardAEMihalikSJ

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For example, recent studies have focused on nanoparticles capable of delivering CpG oligodeoxynucleotides, a potent TLR9 agonist, alongside ICD-inducing agents to synergistically promote dendritic cell maturation and T cell activation [81,82,83]

Free Radic Biol Med, 1999