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Trace elements and oxidative stress indicators in the liver and kidney of the blue shark (Prionace glauca)

Briefly, in a well described mechanism, paracetamol is broken down by membrane-bound cytochrome p450 enzymes such as CYP2E1, CYP1A2 and CYP3A4 to its reactive intermediate, NAPQI which is known to covalently bind to mitochondria and cause direct hepatic toxicity by prompting increased generation of ROS and reactive nitrogen species (RNS) that ultimately drive apoptosis and necrotic cell death [1, 72, 73]

What is Saline Nasal Spray Used For

Cells were seeded at a density of 60,000 cells/cm 2 and allowed to proliferate for 3 days

doi: 10.1007/s12035-019-01712-8 21 DeanO.GiorlandoF.BerkM