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These changes are believed to result from shifts in the central circadian clock that regulate feeding and waking behaviors (Numaguchi et al., 2016)

Researchers have found that human proximal tubule epithelial cell lines exhibited distinct ultrastructural alterations indicative of pyroptosis when exposed to high glucose, and that the expression of TLR4, NLRP3, caspase-1, GSDMD-N, IL-1, and IL-18 are significantly upregulated (124)

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The relative reduction at 25 C was not caused by lack of acclimation capacity, as an even higher CTmax than observed in this study, has been obtained with the use of higher mean temperatures for D