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Exclusion criteria included: studies that did not focus on GPX4s role in pain modulation

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10.1016/j.freeradbiomed.2017.03.011 86 LiY.ChenL.ZhengD.LiuJ

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References 1 DelgoffeGM

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flank: p = 0.1310) (j) and cystine (no tumor vs

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The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]

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