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In the subset of 40 efficacy-evaluable, treatment-nave patients, the ORR was 77.5%, with a CR rate of 25.0%

TMAO can also promote the release of calcium ions into the cells through adenosine diphosphate, thrombin, and collagen, improve the sensitivity of platelets, and then promote thrombosis, which may directly stimulate the occurrence of MI (Zhu et al., 2016)

It also reduces the appearance of hyperpigmentation and wrinkles and shrinks large pores in one session

It has been suggested that AS may be triggered by gut infection with Klebsiella bacteria, but the evidence is circumstantial, based on the observation by some, but not all, investigators of elevated levels of antibodies against Klebsiella pneumoniae in the blood of patients with active disease

To facilitate their broader clinical adoption, future research should focus on several strategic areas