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However, the time required for fibroblasts to reach their normal division limit and mimic cellular senescence has been prolonged

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The X-ray-derived data of small molecular fragments in complex with TGR used in this study to design the compounds here described are available in the PDB under accession codes 6FTC, 6FMU, 6FMZ, 6FP4, 2X99, 2X8G, 2X8H, 6ZST, 6ZP3, 6ZLP, 6ZLB, 7B02, 7NPX, 2V6O, 6RTJ, 6RTO, 6RTM, and 3H4K

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It indicated that the alpha-helicity increased twofold (from 29.2 to 54.1%) with the substitution of the valine at the 12 th position in Cr FAP65AH1