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Although CHKs did not show differential expression at 24 hours post-treatment, it is plausible that such changes may manifest at later timepoints subsequent to RRM2 downregulation

Preparation of fortified white and yellow Asian noodles, including dough kneading, cutting, and drying, led to minimal (1.3%) folic acid losses compared to fortified wheat flour

Acknowledgements This work was supported by the National Natural Science Foundation of China (82272660, 82160456, and 81972399), the Guizhou Provincial Science and Technology Projects (ZK[2022]394), the Excellent Young Talents Plan of Guizhou Medical University ([2020]47), the Natural Science Foundation Research Team of Guangdong Province (2018B030312001), the Plan on Enhancing Scientific Research in GMU (02-410-2302289XM), the Basic and Applied Basic Research Project of the Guangzhou Basic Research Program (202201011411)

There is no official clinical guidance on combining these treatments, as Lipo C formulations are unapproved compounded products not reviewed by the FDA

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