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Results Fast uptake and clearance of tamoxifen and its bioactive metabolite 4-OH-TAM into the brain To analyze the contribution and time course of tamoxifen (TAM) and its metabolites N-desmethyl-tamoxifen (NDM-TAM), 4-hydroxytamoxifen (4-OH-TAM) and endoxifen (END) for cell type-specific recombination, we determined their pharmacokinetic profile by LC-HR-MS/MS

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