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A letter to Clinical Toxicology from Shah, et al., at Carolinas Medical Center, recommended the antidote in very limited cases of severe acetaminophen toxicity, stating that they strongly believed that a single dose of fomepizole had a reasonable balance of potential benefit, safety, and cost to suggest its targeted use on a case-by-case basis until a randomized, controlled trial is performed

if you expose it to liquid too forcefully or shake it violently, you risk damaging the molecular structure (denaturation), which can undermine research quality

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Vitamin B12 deficiency is most common in adults over 50, vegans and vegetarians, pregnant women, and those with chronic health conditions like Crohns disease, inflammatory bowel disease (IBS), or rheumatoid arthritis