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We illustrate significance in the figures of this manuscript with the following conventions: p 0.05 is denoted with *, p 0.01 is denoted with ** and p 0.001 is denoted with ***

In renal tissue, acute or chronic systemic injections of trimetazidine have been shown to reduce thiobarbituric acid reactive substances in immunosuppressant-induced renal dysfunction [178] and prevent SOD, glutathione peroxidase, catalase or glutathione decrease in ischemia/reperfusion injury in rats [179, 180]