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Confocal imaging Tyrosine hydroxylase (TH)-Gal4 driven UAS-GFP lines, labeling the neurons with active dopamine synthesis pathway, were crossed with park 13 flies and progenies were exposed to Sp from 10 days AEL

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Collectively, these findings from the MOXIe program (Part 1, Part 2, and the OLE) suggest that treatment-emergent aminotransferase elevations with omaveloxolone occurred early and were transient and reversible

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Consequently, the inhibition of Gln metabolism is associated with elevated ROS levels, which in turn promotes apoptosis in tumor cells (44)