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Beyond well-known interventions (such as dietary modifications), novel therapeutics (such as small interfering RNA gene silencers, recombinant oxalate-degrading enzymes and oxalate-degrading bacterial strains) hold promise to improve the outlook of patients with oxalate-related diseases

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Favilla V, Russo GI, Privitera S, Castelli T, Madonia M, La Vignera S, et al

Besides being an HDAC inhibitor, microbial butyrate differentially inhibits glucose transport, glycolysis, and DNA synthesis in cancerous colonocytes via inhibiting GLUT1 and glucose-6-phosphate dehydrogenase (G6PD) through the GPR109a-AKT pathway (Geng et al., 2021)