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Previous study [32] also reported that the N-terminal methyltransferase part of NcEgt1 showed a lower catalytic rate than the other part (NcEgt1 could catalyze the substrate histidine or TMH to synthesize Cys-TMH but the reaction rate of using TMH as substrate to perform synthesis was 100-fold fast than using the histidine)

Chin J Integr Tradit Western Med 29:975978 Li Y, Xue WJ, Tian PX, Ding XM, Yan H, Pan XM, Feng XS (2009) Clinical application of cordyceps sinensis on Immunosuppressive therapy in renal transplantation

Beyond simply concentrating on B12 deficiency, it becomes paramount to address the matter of declined sensitivity to B12