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The optimal concentration window stimulates maximum growth, while higher concentrations can trigger inhibitory feedback

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Plasma half-life estimates range from 30-60 minutes based on limited animal and human studies, though systematic pharmacokinetic characterization in humans has not been published

Brain Res 1283:127138 Hesse A, Wagner M, Held J, Bruck W, Salinas-Riester G, Hao Z, Waisman A, Kuhlmann T (2010) In toxic demyelination oligodendroglial cell death occurs early and is FAS independent