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MOFs can deliver oxymatrine (Om) and astragaloside IV (As) into the HCC microenvironment, and increase the oxygen consumption rate and proton efflux rate of tumor-infiltrating lymphocytes (TILs) by regulating the mitochondrial function of CAFs and TILs (213)

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Additionally, in a high-fat diet-induced hypertension mouse model, valproic acid was found to inhibit HDAC1, reducing angiotensin II and its receptor expression, thereby preventing hypertension progression [79]

In a word, as a crucial defensive response in vivo , inflammation is closely associated with CD induced by ferroptosis