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Last accessed: December 2025

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So the connection between ROS, glutathione, and anxiety has been shown in animal studies: we found that anxiety in mice is accompanied by markedly elevated levels of ROS in neuronal and glial cells within the cerebellum and hippocampus, as well as in neurons of the cerebral cortex and in blood monocytes, granulocytes, and lymphocytes Other studies increased oxidative stress via an oxidation boosting chemical which induced anxiety across a range of different genetic types: The anxiogenic behavior due to BSO treatment was observed in several mouse models of anxiety, including elevated plus maze, hole-board, and open field tests