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401 Interestingly, a TRF with equivalent caloric intake from HFD has been shown to have a protective effect on HFD-induced obesity and associated complications by adjusting various signaling pathways and causing rhythmic creatine-mediated thermogenesis, which may further improve nutrient utilization and energy expenditure and reverse excessive daytime sleepiness induced by paraventricular thalamic nucleus (PVT) dysfunction

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However, for patients with severe symptomatic hyponatremia who are particularly prone to overcorrectionespecially those at high risk for ODS where consistent monitoring of laboratory values and urine output is challengingearly use of DDAVP can be considered a proactive and viable strategy

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