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It is important to note that all current evidence derives from in vitro cellular models and in vivo animal studies, and no human clinical trials have been conducted as of February 2026

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Therefore, hospitals cannot remain noncompliant as a course of business and continue to receive a 35 percent CMP reduction

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*Eligible patients without diabetes but with a BMI of 30, or 27 with comorbidities, lost an average of 21% of their body weight (-48 lbs) in a 72-week clinical trial evaluating 15 mg of tirzepatide, when combined with a reduced-calorie diet and increased physical activity