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Closing the knowledge gaps requires a parallel advancement in our experimental and analytical capabilities: Developing artefact-free, relevant mechanistic assays: as noted, the uncritical use of conventional toxicity assays has likely generated a body of data compromised by ENM-specific artefacts

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Metformin, which is well-tolerated due to extensive clinical experience in diabetes management, has shown promising epidemiological associations with reduced cancer incidence and improved outcomes in some studies