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[26] The same critics claimed that previous controlled trials "found no evidence that chelation is superior to placebo for treatment of CAD [Coronary Artery Disease] or PVD [Peripheral Vascular Disease]," making the trial "unethical, dangerous, pointless, and wasteful." [3] Evidence of insurance fraud and other felony convictions among (chelation proponent) investigators further undermined the credibility of the trial

Favorable effects were also observed across multiple cardiometabolic risk markers, including waist circumference, glycemic parameters, insulin levels, triglycerides, and C-reactive protein

Muscle disorders For instance, multiple studies have observed alterations at the molecular level in NAD + metabolism and mitochondrial homeostasis in skeletal muscle, associated with muscle loss and functional decline

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Animal data show that AF can cause renal vasoconstriction and decreased renal blood flow and even renal fibrosis or possibly renal micro-infarcts [40, 41]