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Insecticide resistance often incurs a metabolic cost, so downregulated genes may reflect suppression of non-essential pathways to conserve resources

In practice, if a therapy is considered, success should be defined with measurable endpointssleep quality, function, waist circumference/body composition (when appropriate), and metabolic markersrather than vague claims alone

10.1016/j.jhep.2012.04.033 115

Introduction to Lipids and Lipoproteins

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