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The Prohibited List is broken down into three parts: If a substance or method is on or is added to the List, it meets at least two of the following three criteria: Of the substances and methods prohibited at all times , there are six substance categories: S0 (non-approved substances), S1 (anabolic agents), S2 (peptide hormones, growth factors, related substances and mimetics), S3 (beta-2 agonists), S4 (hormone and metabolic modulators) and S5 (diuretics and masking agents)

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Research on MOTS-c in ovariectomized mice (a model for postmenopausal metabolic dysfunction) showed reduced fat accumulation in white adipose tissue, increased brown fat activation, and improved insulin sensitivity after just 5 weeks of treatment