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Undeniably, the understanding of cellular zinc metabolism and zinc signaling is still evolving, and future investigations in this field are promising

This phenomenon presents a promising opportunity for designing drug delivery systems that specifically target tumors

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HIF bind to HIF-responsive elements (HRE) in the erythropoietin promoter, stimulating transcription (Souma et al 2015) and increasing erythropoietin production

NLRP3 Activation by Heme in Macrophages Heme has a synergistic effect with microbial molecules on macrophages, increasing the production of inflammatory cytokines in a mechanism dependent of ROS and spleen tyrosine kinase (Syk) (102)