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Discontinuation criteria protect patients from progressive organ damage: AST/ALT exceeding 40 IU/L Bilirubin above 21 mol/L Creatinine surpassing 90 mol/L in females These safety parameters require immediate cessation of therapy to prevent irreversible organ damage

To explore alternative mechanismsespecially its reported effect on intestinal glucose uptakewe aimed to minimize the confounding influence of incretin signaling

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