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Furthermore, the formation of autophagic vacuoles and upregulation of autophagy-related genes in juglanin-treated cells indicate that juglanin also induces cellular autophagy (Yang et al., 2023a)

attempted to prevent hepatotoxicity in massive APAP overdoses by doubling the rate of NAC infusion over the last 16 hours, giving patients 12.5 mg/kg/h instead of the standard 6.25 mg/kg/h

Existing studies indicate that quetiapine can cause mitochondrial dysfunction, while therapeutic doses of aripiprazole show significant antioxidant protective effects under acute oxidative stress conditions in vitro (20)

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Moreover, suppression of BCAA catabolic enzyme expression led to reduced cell proliferation and BCAA accumulation in liver carcinogenesis but not in regenerating liver tissues (Ericksen et al., 2019)