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Rapamycin-induced autophagy ameliorates GSH depletion-induced premature cell senescence It was shown that autophagy activation especially in the presence of an increasing autophagic flux inhibits the senescence of RPE cells 35,36,37,38,39

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An emerging aspect to keep in mind is that besides the prevalence of ALD, alcohol consumption also occurs in the context of obesity and MASLD, leading to a new paradigm where alcohol intake coexists with metabolic alterations and cardiovascular risks, coined MetALD and covered in the section Metabolic liver diseases, which accounts for most cases of chronic metabolic liver disease and alcohol consumption