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If free copper ions were the active mechanism, supplementing oral copper would be more effective, and there is no evidence that it is

Pharmacopsychiatry 46 , 120121 (2012)

doi:10.1016/s0024-3205(00)00803-1

This is for several reasons: Abundant subcutaneous tissue: The abdomen typically has sufficient subcutaneous fat tissue, even in lean individuals

Lancet 356:469474 Sokol RJ, Twedt D, McKim JM Jr., Devereaux MW, Karrer FM, Kam I et al (1994) Oxidant injury to hepatic mitochondria in patients with Wilsons disease and Bedlington terriers with copper toxicosis