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Our guide on drinking on tirzepatide covers this in detail

Stop the medication and contact your prescriber or NHS 111 (or 999 for the allergic reactions below) if you experience: Signs of a severe allergic reaction Difficulty breathing or swallowing Swelling of the face, lips, tongue, or throat Widespread severe rash or itching Rapid heartbeat with feeling faint Signs of pancreatitis Severe upper-abdominal pain that may spread to the back Pain that doesnt go away and may worsen after eating Severe nausea and vomiting alongside the pain Signs of gallbladder problems Pain in the upper right side of the abdomen, often after eating Fever Yellowing of skin or eyes (jaundice) Clay-coloured stools Signs of severe dehydration Unable to keep fluids down for more than 24 hours Very dark urine, or not passing urine Severe dizziness or confusion Signs of kidney problems Decreased urination Swelling in legs or ankles Persistent severe tiredness Questions to ask your GP Before starting a weight-loss injection, work through these with your prescriber: Eligibility Are there any reasons I shouldnt take this

Tolerance considerations: Reported effects can be dose-sensitive, and adverse reactions such as nausea, flushing, fatigue , and changes in freckles/moles are commonly cited